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, Sayed Haidar Abbas Raza Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University , Guangzhou 510642 , China Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University , Shaoguan 512005 , China College of Animal Science and Technology, Northwest A&F University , Yangling, Shaanxi 712100 , P.R. China Search for other works by this author on: Oxford Academic Ruimin Zhong Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University , Shaoguan 512005 , China Search for other works by this author on: Oxford Academic Xiangmei Li Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University , Guangzhou 510642 , China Search for other works by this author on: Oxford Academic Sameer D Pant Gulbali Institute, Charles Sturt University , Wagga Wagga, NSW 2678 , Australia Search for other works by this author on: Oxford Academic Xing Shen Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University , Guangzhou 510642 , China Search for other works by this author on: Oxford Academic Mona N BinMowyna College of Education, Shaqra University , Shaqra 11911 , Saudi Arabia Search for other works by this author on: Oxford Academic Lin Luo Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University , Guangzhou 510642 , China Corresponding author. Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, China. E-mail: lin.luo@scau.edu.cn Search for other works by this author on: Oxford Academic Hongtao Lei Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University , Guangzhou 510642 , China Guangdong Laboratory for Lingnan Modern Agriculture , Guangzhou 510642 , China Corresponding author. Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, China. E-mail: hongtao@scau.edu.cn Search for other works by this author on: Oxford Academic
Journal of Pharmacy and Pharmacology, rgae133, https://doi.org/10.1093/jpp/rgae133
Published:
25 October 2024
Article history
Received:
18 June 2024
Accepted:
04 October 2024
Published:
25 October 2024
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Sayed Haidar Abbas Raza, Ruimin Zhong, Xiangmei Li, Sameer D Pant, Xing Shen, Mona N BinMowyna, Lin Luo, Hongtao Lei, Ganoderma lucidum triterpenoids investigating their role in medicinal applications and genomic protection, Journal of Pharmacy and Pharmacology, 2024;, rgae133, https://doi.org/10.1093/jpp/rgae133
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Abstract
Objectives
Ganoderma lucidum (GL) is a white rot fungus widely used for its pharmacological properties and health benefits. GL consists of several biological components, including polysaccharides, sterols, and triterpenoids. Triterpenoids are often found in GL in the form of lanostane-type triterpenoids with quadrilateral carbon structures.
Key findings
The study revealed that triterpenoids have diverse biological properties and can be categorized based on their functional groups. Triterpenoids derived from GL have shown potential medicinal applications. They can disrupt the cell cycle by inhibiting β-catenin or protein kinase C activity, leading to anti-cancer, anti-inflammatory, and anti-diabetic effects. They can also reduce the production of inflammatory cytokines, thus mitigating inflammation. Additionally, triterpenoids have been found to enhance the immune system’s defenses against various health conditions. They possess antioxidant, antiparasitic, anti-hyperlipidemic, and antimicrobial activities, making them suitable for pharmaceutical applications. Furthermore, triterpenoids are believed to afford radioprotection to DNA, protecting it from radiation damage.
Summary
This review focuses on the types of triterpenoids isolated from GL, their synthesis pathways, and their chemical structures. Additionally, it highlights the pharmacological characteristics of triterpenoids derived from GL, emphasizing their significant role in various therapeutic applications and health benefits for both humans and animals.
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Ganoderma lucidum, triterpenoids, therapeutic applications, genomic guardian
© The Author(s) 2024. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
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