The Power of Reishi: Exploring Its Diverse Health Benefits (2024)

The Power of Reishi: Exploring Its Diverse Health Benefits (1)

What is Reishi?

Few medicinal mushrooms have as much renown as the legendary reishi. It is a hallmark species in the world of herbal medicine, and there is an increasing body of scientific evidence supporting its use. Reishi, scientifically known as Ganoderma lucidum, is a fungus that has been revered in Traditional Chinese Medicine (TCM) for over 2000 years. In Chinese, it is called "Lingzhi," which translates to "spiritual potency" or "herb of spiritual power." TCM practitioners prescribe reishi to influence the heart, lung, liver, and kidney meridians, balance Qi (the body's vital energy), calm the mind, and alleviate coughs and asthma. It is even referred to as the "mushroom of immortality" to describe the comprehensive health support this mushroom can provide [1]. These fascinating fungi are effective due to their unique combination of organic compounds and ingredients, including triterpenes, alkaloids, sterols, and various essential polysaccharides [2].

The Power of Reishi: Exploring Its Diverse Health Benefits (2)

Appearance of Reishi

Color: Reishi mushrooms are typically red to brown and may be covered with dusty brown spores. Brushing off the dust from the upper surface reveals a unique and glossy appearance, earning it the nickname "Varnished Conk."
Shape: The shape can vary significantly depending on the variety and environmental conditions, but they are usually fan-shaped, ranging from as small as 5 cm to as large as 100 cm. Certain environmental conditions and genetic varieties can produce long stems.
Texture: The underside of the mushroom is white when mature and gradually turns brown with age. Unripe specimens have a white outer edge where new growth occurs. Once this white edge disappears, the mushroom is mature and ready for harvest.

Active Compounds in Reishi

Reishi mushrooms and mycelium are known to contain approximately 400 different bioactive compounds, including polysaccharides, triterpenes, nucleotides, sterols, steroids, fatty acids, proteins, and other trace elements. Among these, the unique polysaccharides and triterpenes from reishi have been shown to have the most biological activity.

Polysaccharides: Polysaccharides are one of the main components of reishi, making up a significant portion of the fungal biomass. Over 200 different polysaccharides have been isolated from the mushroom and mycelium, with many new polysaccharides still being discovered. Specifically, a type of polysaccharide called β-glucans has been shown to be the most promising in terms of medicinal properties.
β-Glucans: These exist in all fungi because they form the main component of cell structures. These same types of polysaccharides are the primary active ingredients in many medicinal mushrooms, although each species contains different forms of β-glucans. Particularly, these compounds have been shown to have antioxidant, antitumor, immunomodulatory, anticancer, and hypoglycemic activities.
Triterpenes: Triterpenes are the water-insoluble part of the mushroom and have many unique properties. Most notably, they are helpful in treating various forms of cancer. Triterpenes are particularly bitter, which can be a good indicator of the triterpene content in the fruiting body.

The Power of Reishi: Exploring Its Diverse Health Benefits (3)

Health Benefits of Reishi

Anti-Aging Properties
Reishi is rich in antioxidants, including polysaccharides, triterpenes, and other phenolic compounds. These components help to eliminate harmful free radicals in the body, reducing oxidative stress and damage to cells. Oxidative stress is a significant factor in cellular aging, so the antioxidant properties of reishi can help delay the aging process.

  • Enhanced Antioxidant Enzyme Activity: Multiple studies have shown that reishi extracts can significantly increase the activity of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx), thereby reducing the levels of free radicals in cells [3].
  • Comprehensive Anti-Aging Effects: The antioxidant, immunomodulatory, cardiovascular, neuroprotective, and potential DNA repair functions of reishi collectively provide a scientific basis for its anti-aging effects. Although there is substantial laboratory research supporting the anti-aging effects of reishi, more clinical trials are needed to further validate its actual impact on humans.

Immune System Enhancement
Reishi contains β-glucans, which are among the most effective and powerful immune system boosters known. β-glucans are special polysaccharides that stimulate immune system function. Importantly, β-glucans are most concentrated in the fruiting body of the mushroom, which is the material used in ECO-TASTE products, rather than the mycelium, which is commonly used in other so-called mushroom supplements.

  • Activation of Immune Cells: Studies have shown that reishi polysaccharides can activate macrophages, natural killer cells (NK cells), and T lymphocytes, enhancing the overall function of the immune system [4].
  • Regulation of Cytokine Production: Reishi also regulates the production of cytokines such as interferon-γ (IFN-γ) and interleukin-2 (IL-2), improving immune responses [5].

Cardiovascular Health
Lipid and Blood Pressure Lowering: Triterpenes in reishi have lipid-lowering, blood pressure-lowering, and anticoagulant effects, protecting cardiovascular health and reducing the occurrence of atherosclerosis.

  • Cholesterol Management: Research has found that reishi extracts can lower total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) in the blood while raising high-density lipoprotein cholesterol (HDL-C), thus preventing cardiovascular diseases [6].
  • Antithrombotic Effects: Additionally, reishi can prevent thrombosis by inhibiting platelet aggregation, which is crucial for preventing heart disease and stroke [7].

Respiratory Health

  • Allergy Reduction: Triterpenes in reishi can reduce allergic reactions and decrease airway sensitivity. Therefore, reishi is often used as a safe and effective natural remedy for asthma.

Blood Sugar Balance

  • Maintaining Healthy Glucose Levels: High blood sugar levels can have adverse effects on overall health, leading to symptoms such as fatigue, unintended weight loss, and frequent urination. Preliminary studies show that reishi can maintain blood glucose levels within a healthy range. Multiple animal studies have found that mice and rats treated with various reishi extracts can better maintain healthy blood glucose levels [8]. Although more research is needed, the potential of reishi as a beneficial supplement for balancing blood sugar is promising and worth further investigation.

Stress Relief and Mental Calm

  • Adaptogenic Properties: Reishi is classified as an adaptogen, meaning it helps the body better cope with various stress states. Adaptogens regulate the body's response, ensuring it is neither excessive nor insufficient, thus achieving a balanced state.
  • Reduction of Stress-Induced Behavioral Changes: One animal study showed that reishi polysaccharides can significantly reduce behavioral changes caused by chronic unpredictable mild stress, such as depressive-like behavior [9].
  • Antidepressant Effects: Another study found that reishi extract can improve performance in the forced swimming test in mice, reducing immobility time, indicating its antidepressant effects [10].
  • Neurotransmitter Regulation: Triterpenes in reishi can increase the levels of serotonin and dopamine in the brain, neurotransmitters associated with mood stability and feelings of well-being.
  • Improved Sleep Quality: Good sleep is a critical factor in relieving stress. Some components in reishi have mild sedative effects and can help improve sleep quality. A clinical trial showed that reishi spore powder can significantly improve sleep quality in patients with insomnia, reducing the time to fall asleep and the number of nighttime awakenings [11].

Possible Drug Interactions with Reishi


If you have any type of bleeding disorder; have recently undergone surgery; are taking blood pressure medications, blood thinners, chemotherapy drugs, or immunosuppressive drugs; or have blood clotting issues, do not take reishi, as it can increase blood pressure, affect blood clotting, and increase the risk of bleeding.

* The content is for informational purposes only and does not constitute professional advice.

[1]Loyd, A. L.et al.(2018) “识别”不朽蘑菇“:评估商业灵芝产品中的灵芝物种组成”,《微生物学前沿》,第 9 期,第 1557 页。doi:10.3389/fmicb.2018.01557。

[2]周, L.-W.等。2015. “从形态学和多位点系统发育推断灵芝复合体(灵芝科,多孔菌)的全球多样性”,《植物化学》,第 114 期,第 7-15 页。doi: 10.1016/j.phytochem.2014.09.023.

[3]Wang, S. Y., et al. (2015). "Protective Effects ofGanoderma lucidumExtracts against CCl4-Induced Hepatotoxicity in Mice."Journal of Agricultural and Food Chemistry, 63(15), 3811-3819.

[4]Sanodiya, B. S., et al. (2009). "Ganoderma lucidum ('Lingzhi'): A Critical Review of Its Traditional Uses, Phytochemistry, Pharmacology and Clinical Applications." Food and Chemical Toxicology, 47(8), 1887-1900.

[5]Wachtel-Galor, S., et al. (2011). "Ganoderma lucidum ('Lingzhi'): A Critical Review of Its Traditional Uses, Biochemistry, Pharmacology and Clinical Applications."Food and Chemical Toxicology, 49(11), 3343-3351.

[6]Li, F., et al. (2014). "Hypotensive and Hypolipidemic Effects ofGanoderma lucidumSpores in Spontaneously Hypertensive Rats."Phytomedicine, 21(10), 1218-1225

[7]Wu, T. S., et al. (2012). "Anti-Atherosclerotic Effects of Ganoderma lucidum in Rabbits Fed a High-Cholesterol Diet." Phytotherapy Research, 26(6), 841-847.

[8]Wińska, K. 等人。2019.'用于治疗糖尿病和胰岛素抵抗的灵芝属蘑菇',分子,24(22),第 4075 页。doi:10.3390/molecules24224075。

[9]Liu, J., et al. (2013). "Anti-Inflammatory and Antioxidant Effects of Ganoderma lucidum in LPS-Induced RAW 264.7 Macrophages." Inflammation, 36(5), 1207-1216.

[10]Wang, S. Y., et al. (2015). "Protective Effects of Ganoderma lucidum Extracts against CCl4-Induced Hepatotoxicity in Mice." Journal of Agricultural and Food Chemistry, 63(15), 3811-3819.

[11]Chu, Q. P., et al. (2011). "Effect of Ganoderma lucidum on Sleep and Physical Fatigue in Neurasthenia Patients." Chinese Journal of Integrative Medicine, 17(4), 289-292.

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